Background: KP-1461 is a prodrug to KP-1212.KP-1212 is a viral mutagen designed to increase viral error rate.Methods: We describe 2 phase I studies: KP1461-101 (double-blind, placebo-controlled, single, escalating doses, 100 Insulated Beverage Server Lids to 1600 mg study in 42 non-HIV-infected participants) and KP-1461-102 (double-blind placebo-co
Reconfigurable Power Divider-Enabled Dynamic Hybrid m-MIMO Transmitter
A promising solution for massive Multiple-Input Multiple-Output (m-MIMO) systems is Hybrid digital-analogue (HDA) beamforming as it offers a balanced trade-off between energy efficiency (EE) and spectral efficiency (SE).The lack of practical demonstrations in the open literature is primarily because those most existing works require a large Footwea
Aldehyde Dehydrogenase 2 Protects Against Post-Cardiac Arrest Myocardial Dysfunction Through a Novel Mechanism of Suppressing Mitochondrial Reactive Oxygen Species Production
Post-cardiac arrest myocardial dysfunction significantly contributes to early mortality after the return of spontaneous circulation.However, no effective therapy is available now.Aldehyde dehydrogenase 2 (ALDH2) enzyme has been shown to protect the heart from aldehyde toxicity such as 4-hydroxy-2-nonenal (4-HNE) and oxidative stress.In this study,
Board of discord: Conflicting preferences and performance pay
AbstractThis study examines the Ultimate Repair Mask interaction of conflicting preferences among directors, performance pay, and group effort.I model a corporate board in which directors voluntarily choose to research (or not research) an investment decision made by the board on behalf of the firm.Free-riding among directors creates a need for per